Respiratory failure & ventilation
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial
Primary result · 28-day mortalityResult — go to the resultRelative risk 1.11 95% CI 0.9–1.4- stopped prematurely (COVID-19 pandemic)
- Stopped prematurely because of the COVID-19 pandemic
Authors' conclusion
Among mechanically ventilated ICU patients with an expected mechanical ventilation duration of at least 24 hours, using a low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy.
Study context
- Population
- Mechanically ventilated ICU patients with expected ventilation duration of at least 24 hoursof planned 1,512
- Participants
- 664 participants
- Comparison
- Low- vs high-oxygenation target
- Low-oxygenationn = 335
- High-oxygenationn = 329reference
- Primary endpoint
- Mortality
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Primary result
28-day mortality · Day 28
Relative risk
1.11
95% CI 0.9–1.4
P = 0.30
Events by treatment group
Low-oxygenation vs High-oxygenation
RR 1.11 (95% CI 0.9–1.4); P = 0.30
As reported in the abstract
Further findings
Achieved PaO2
Safety
At least one serious adverse event
Original publication
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial. Am J Respir Crit Care Med. Published 1 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →