Respiratory failure & ventilation

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis

Br J AnaesthPublished Ecological country-level analysis

Authors' conclusion

Conservative oxygenation strategies reduce oxygen-related costs and emissions.

Study context

Population
Mechanically ventilated critically ill adults; 2024 country-level aggregate data200 countries
Comparison
Conservative vs liberal oxygenation targets
Outcome
Total oxygen consumption costs (2024 int$) and associated greenhouse gas emissions (ktCO2eq)
Follow-up
Annual
Methodological detailsMonte-Carlo simulation, Bayesian multivariable regression, scenario analyses
  • Monte-Carlo simulation
  • Bayesian multivariable regression
  • Scenario analyses

Main finding

As reported in the abstract

Difference

104 million int$

global annual expenditures 180 (liberal) to 76 (conservative) million int$

Difference

516 ktCO2eq

emissions 884 (liberal) to 368 (conservative) ktCO2eq

Further findings

Determinants of oxygen-related costs

Lower costs in countries with higher GDP per capita; higher with greater PM2.5 exposure and higher out-of-pocket health spending

Per-ICU bed greenhouse gas emissions

Highest in the Eastern Mediterranean, Central Asia and upper-middle-income countries; higher fossil-fuel electricity share and hospital-bed density associated with increased emissions

Decarbonisation scenarios

Cleaner grids would reduce global oxygen-related emissions
49.4%-91.9%

Original publication

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis. Br J Anaesth. Published 1 July 2026. doi:10.1016/j.bja.2026.05.012

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