Respiratory failure & ventilation
Effects of a lower versus a higher oxygenation target in intensive care unit patients with chronic obstructive pulmonary disease and acute hypoxaemic respiratory failure: a subgroup analysis of a randomised clinical trial
Primary result · Mortality (COPD subgroup)Result — go to the resultRelative risk 0.98 95% CI 0.82–1.17Authors' conclusion
In ICU patients with COPD and acute hypoxaemia, a lower vs a higher oxygenation target did not reduce mortality.
Study context
- Population
- Intensive care unit (ICU) patients with chronic obstructive pulmonary disease (COPD) and acute hypoxaemiaCOPD subgroup of 2928
- Participants
- 563 patients
- Comparison
- Lower vs higher oxygenation target
- Lowern = 277
- Highern = 286reference
- Primary endpoint
- Mortality
- Follow-up
- Up to 90 days
Methodological detailspre-planned subgroup analysis, stratified allocation
- Pre-planned subgroup analysis
- Stratified allocation
Primary result
Mortality (COPD subgroup)
Relative risk
0.98
95% CI 0.82–1.17
P = 0.67
Events by treatment group
Lower vs Higher
RR 0.98 (95% CI 0.82–1.17); P = 0.67
As reported in the abstract
Secondary outcomes
PaO2 after allocation
PaCO2 (time-weighted average)
- PaCO2 (time-weighted average): data for 497 patients (88%)
PaCO2 (time-weighted average)
- No between-group difference
Secondary outcomes
- No statistically significant differences in any secondary outcome
Original publication
Effects of a lower versus a higher oxygenation target in intensive care unit patients with chronic obstructive pulmonary disease and acute hypoxaemic respiratory failure: a subgroup analysis of a randomised clinical trial. BJA Open. Published 29 April 2024. doi:10.
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