Long‐term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT‐ICU and HOT‐COVID trials: A protocol update

Crescioli, E; Riis, JØ; Weinreich, UM; Jensen, JUS; Poulsen, LM; Brøchner, AC; Lange, T; Perner, A; Klitgaard, TL; Schjørring, OL; Rasmussen, BS

doi:10.1111/aas.14379

Long‐term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT‐ICU and HOT‐COVID trials: A protocol update

Acta Anaesthesiol ScandPublished 25 Jan 2024Protocol and statistical analysis plan update for secondary outcomes of the Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) and HOT-COVID randomised trials

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Study context

Population: Adult ICU patients with acute hypoxaemic respiratory failure (HOT-ICU) or confirmed COVID-19 (HOT-COVID), enrolled at selected Danish sites and surviving to 1 year after randomisation

Planned comparison: Lower vs higher oxygenation target
Primary endpoint: Long-term cognitive function (Repeatable Battery for the Assessment of Neuropsychological Status score) and long-term pulmonary function (full-body plethysmography incl. diffusion capacity for carbon monoxide)
Follow-up: 1 year after randomisation

Methodological detailsmulticentre, parallel-group, pre-planned secondary outcomes, Last patient expected to be included in spring 2024

Multicentre
Parallel-group
Pre-planned secondary outcomes
Last patient expected to be included in spring 2024

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Long‐term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT‐ICU and HOT‐COVID trials: A protocol update. Acta Anaesthesiol Scand. Published 25 January 2024. doi:10.1111/aas.14379

Read the original article ↗

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