Respiratory failure & ventilation
Lower versus higher oxygenation targets in hypoxaemic intensive care unit (ICU) patients after cardiac arrest
Primary result · MortalityResult — go to the resultAdjusted relative risk 1.09 95% CI 0.92–1.28Authors' conclusion
A lower oxygenation target in adult ICU patients with hypoxaemic respiratory failure after cardiac arrest did not result in lower mortality, but fewer SAEs occurred in this group compared to the higher-oxygenation group.
Study context
- Population
- Adult ICU patients with hypoxaemic respiratory failure after cardiac arrestcardiac arrest subgroup
- Participants
- 335 patients
- Comparison
- Lower vs higher oxygenation target
- Lower-oxygenationn = 149
- Higher-oxygenationn = 186reference
- Primary endpoint
- Mortality
- Follow-up
- Up to 90 days
Methodological detailssubgroup analysis, international, exploratory
- Subgroup analysis
- International
- Exploratory
Primary result
As reported in the abstract
Adjusted relative risk
1.09
95% CI 0.92–1.28
P = 0.32
Events by treatment group
Lower-oxygenation vs Higher-oxygenation
adjusted RR 1.09 (95% CI 0.92–1.28); P = 0.32
Secondary outcomes
| Outcome | Adjusted RR (95% CI) | P value | |
|---|---|---|---|
| Mortality · up to one year | 1.05 (0.90–1.21) | P = 0.53 | |
| 0.512Adjusted relative risk (log scale) |
Other secondary outcomes
- No statistically significant differences
Safety
| Outcome | Lower-oxygenation | Higher-oxygenation | Adjusted RR (95% CI) | P value | |
|---|---|---|---|---|---|
| SAEs in the ICUMainly more new shock episodes with higher target | 23% | 38% | 0.61 (0.43–0.86) | P = 0.005 | |
| 0.512Adjusted relative risk (log scale) |
Original publication
Lower versus higher oxygenation targets in hypoxaemic ICU patients after cardiac arrest. Resuscitation. Published 16 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →