Respiratory failure & ventilation
Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome
Authors' conclusion
The association between ventilator variables and mortality varied among patients with different lung morphology. [(4×DP) + RR] was only associated with mortality in patients with non-focal lung morphology.
Study context
- Population
- Adult acute respiratory distress syndrome (ARDS) patients on invasive mechanical ventilation for at least 24 h64.1% non-focal
- Participants
- 396 patients
- Exposure
- Non-focal vs Focal
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsdatabase study (Chinese Database in Intensive Care), extended Cox regression
- Database study (Chinese Database in Intensive Care)
- Extended Cox regression
Main finding
As reported in the abstract
28-day mortality associated with [(4×DP) + RR], by lung morphology
Hazard ratio (95% CI)
Non-focalper [(4×DP) + RR]; significant
1.036(1.027–1.045)
Focalper [(4×DP) + RR]; not significant
1.019(0.999–1.039)
Per [, as printed
- Time-varying driving pressure (DP) more significantly associated with 28-day mortality in non-focal vs focal
- P for interaction = 0.0039
Observational data: associations, not effects.
Further findings
- Overall 28-day mortality
- 34.4%
- Non-focal: more severe and persistent pulmonary mechanical dysfunction and higher mortality than focal
Original publication
Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome. Crit Care. Published 13 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →