Pediatric anesthesia & critical care
Lung Ultrasound Score, Severity of Acute Lung Disease, and Prolonged Mechanical Ventilation in Children
Authors' conclusion
In critically ill children, the lung US score early after admission may predict prolonged IMV.
Study context
- Population
- Children aged 1 month to 18 years requiring respiratory support in the ICU, excluding chronic parenchymal lung disease
- Participants
- 538 children
- Exposure
- Prolonged invasive mechanical ventilation (IMV) vs no prolonged IMV
- Prolonged IMVn = 62
- Outcome
- Lung US score at 12 h predicting prolonged IMV
- Follow-up
- 12 hours
Methodological detailsmulticentre, prognostic accuracy
- Multicentre
- Prognostic accuracy
Main finding
As reported in the abstract
AUROC, lung ultrasonography (US) score alone
0.87
95% CI 0.81–0.93
AUROC, multivariable model, derivation
0.92
95% CI 0.89–0.95
AUROC, multivariable model, internal validation
0.91
95% CI 0.90–0.92
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Lung US score · 12 hoursProlonged mechanical ventilation vs No prolonged mechanical ventilation | Prolonged mechanical ventilation median 24 (IQR 19–26) | P < 0.001 |
| Lung US score · 48-72 hoursProlonged mechanical ventilation vs No prolonged mechanical ventilation | Prolonged mechanical ventilation median 16 (IQR 10.5–22.5) | P < 0.001 |
Correlation of lung US score with oxygenation · 12 hours
- Oxygenation index R2 (95% CI 0.293-0.566); ρ −0.705; P < 0.001
- 0.435
- Oxygen saturation index R2 (95% CI 0.370-0.613); ρ 0.651; P < 0.001
- 0.499
Multivariable model including lung US score for prolonged IMV (AUROC)
- Derivation AUROC
- 0.92 (95% CI 0.89-0.95)
- Internal validation AUROC
- 0.91 (95% CI 0.90-0.92)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lung Ultrasound Score, Severity of Acute Lung Disease, and Prolonged Mechanical Ventilation in Children. Am J Respir Crit Care Med. Published 1 January 2025. doi:10.
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