Lymphopenia and mortality in adult sepsis: A systematic review and focused meta-analysis of prognostic evidence
Pooled result · MortalityResult — go to the resultPooled relative effect 1.94 95% CI 1.39–2.70Authors' conclusion
Lymphopenia-related phenotypes are associated with mortality in adult sepsis, but the small quantitative evidence base and moderate-to-substantial heterogeneity limit the precision and generalizability of the pooled effect.
Study context
- Population
- Adults with sepsis29 studies
- Comparison
- Adverse lymphopenia-related phenotypes vs none
- Outcome
- Mortality
Methodological detailsrandom-effects generic inverse-variance model, leave-one-out analyses
- Random-effects generic inverse-variance model
- Leave-one-out analyses
Pooled result
As reported in the abstract
Pooled relative effect
1.94
95% CI 1.39–2.70
Further pooled results
Leave-one-out sensitivity analyses
- Direction of association retained; heterogeneity sensitive to individual studies
Pathogen-specific associations
- Pathogen-related observations insufficient for pathogen-specific quantitative inference
Original publication
Lymphopenia and mortality in adult sepsis: A systematic review and focused meta-analysis of prognostic evidence. J Crit Care. Published 19 September 2026. doi:10.
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