Respiratory failure & ventilation
Magnitude and time to peak oxygenation effect of prone positioning in ventilated adults with COVID‐19 related acute hypoxemic respiratory failure
Authors' conclusion
In ventilated adults with COVID-19 acute hypoxemic respiratory failure, peak PaO2 :FIO2 ratio effect occurred during the first prone positioning episode and after 9 h. Subsequent episodes also improved oxygenation but with diminished effect on PaO2 :FIO2 ratio.
Study context
- Population
- Invasively ventilated adults with acute hypoxemic respiratory failure secondary to COVID-19 treated with prone positioning
- Participants
- 220 participants · 548 prone episodes
- Exposure
- PaO2:FiO2 ratio before vs during prone positioning
- Outcome
- Magnitude of peak PaO2:FiO2 ratio effect during prone positioning
Main finding
As reported in the abstract
PaO2:FiO2 ratio, first prone episode
Mean PaO2:FiO2 ratio before first prone episode
125
Peak mean PaO2:FiO2 ratio during first prone episode (p < .001)
196
Observational data: associations, not effects.
Further findings
Time to peak PaO2:FiO2 ratio effect
- Peak effect achieved during first episode after hours in prone position (±5); maintained until return to supine
- 9
Prone positioning dose
- Mean (±SD) number of prone episodes (±2)
- 3
- Mean (±SD) hours per episode (±3)
- 16
- Pre-proning PaO2:FiO2 ratio, all prone episodes (±49)
- 137
Original publication
Magnitude and time to peak oxygenation effect of prone positioning in ventilated adults with COVID‐19 related acute hypoxemic respiratory failure. Acta Anaesthesiol Scand. Published 9 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →