Cardiac arrest & resuscitation
Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest
Authors' conclusion
Elevated ICU admission levels of OPN and MPO predicted disturbances in cEEG during the subsequent 48 h after cardiac arrest.
Study context
- Population
- Unconscious, mechanically ventilated ICU-treated adult OHCA survivors with initial shockable rhythm
- Participants
- 112 participants
- Comparison
- Poor vs good grade 48-hour cEEG by inflammatory biomarker levels
- Primary endpoint
- Disturbed 48-hour continuous EEG (cEEG grading) by ICU admission inflammatory biomarker levels
- Follow-up
- 48 h
Methodological detailsobservational, post hoc sub-study
- Observational
- Post hoc sub-study
Primary result
As reported in the abstract
Poor grade 48-hour cEEG
Estimate (95% CI)
Higher ICU admission OPN
OR 3.18 per ln[ng/ml](1.25–8.11)
Higher ICU admission MPO
OR 2.34(1.30–4.21)
Per ln[ng/ml], as printed
- Higher osteopontin (OPN) at ICU admission associated with poor grade cEEG
- P = 0.03
- Higher myeloperoxidase (MPO) at ICU admission associated with poor grade cEEG
- P < 0.01
- Higher resistin at ICU admission associated with poor grade cEEG
- P = 0.01
Further findings
Poor 6-month neurological outcome (CPC 3-5)
P < 0.001
Fixed effect of poor 6-month outcome on daily biomarker levels (ICU admission to 72 h)
- Procalcitonin (PCT)
- F = 7.7, p < .01
- High-sensitivity C-reactive protein (hsCRP)
- F = 4.0, p < .05
- OPN
- F = 5.6, p < .05
Independent prediction of poor 6-month outcome (model with 48-hour neurofilament light (NFL))
- Biomarkers had no independent predictive value
Original publication
Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest. Acta Anaesthesiol Scand. Published 12 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →