Hemodynamics, fluids & transfusion
Mean Arterial Pressure Targets and Patient-Important Outcomes in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Trials*
Pooled result · MortalityResult — go to the resultRelative risk 1.06 95% CI 0.98–1.15Authors' conclusion
In conclusion, our systematic review and meta-analysis demonstrated with moderate certainty that there is no difference in mortality when a higher MAP is targeted in critically ill adult patients with shock.
Study context
- Population
- Adults with shock requiring vasoactive medications
- Participants
- 3,690 adults · 6 RCTs
- Comparison
- Higher mean arterial pressure (MAP) vs lower MAP target
- Outcome
- Mortality
Pooled result
As reported in the abstract
Relative risk
1.06
95% CI 0.98–1.15
P = 0.12
Higher MAP vs Lower MAP
RR 1.06 (95% CI 0.98–1.15); P = 0.12
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| RRTI2 = 24% · moderate certainty | 0.96 (0.83–1.11) | P = 0.57 | |
| RRT (subgroup analysis, patients with vs without chronic hypertension)I2 = 0% | 0.83 (0.71–0.98) | P = 0.02 | |
| 0.512Relative risk (log scale) |
Original publication
Mean Arterial Pressure Targets and Patient-Important Outcomes in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Trials*. Crit Care Med. Published 18 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →