Hemodynamics, fluids & transfusion
Mortality effect of higher versus lower blood pressure targets in vasodilatory shock: an updated systematic review and meta-analysis
Pooled result · 28-day mortalityResult — go to the resultRelative risk 1.10 95% CI 1.01–1.19Authors' conclusion
In patients with vasodilatory shock, universal high MAP targets are associated with increased mortality compared with lower targets, with moderate certainty.
Study context
- Population
- Adults with vasodilatory shock
- Participants
- 3,873 adults · 4 randomised controlled trials (RCTs)
- Comparison
- Higher vs lower mean arterial pressure (MAP) target
- Outcome
- All-cause mortality
Methodological detailsrandom-effects models, subgroup analyses, Bayesian methods, PRISMA
- Random-effects models
- Subgroup analyses
- Bayesian methods
- PRISMA
Pooled result
28-day mortality · 28 days
Relative risk
1.10
95% CI 1.01–1.19
P = 0.03
Higher MAP target vs Lower MAP target
RR 1.10 (95% CI 1.01–1.19); P = 0.03
As reported in the abstract
- Bayesian posterior probability of harm
- 97.8%
Further pooled results
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| RRT-free daysFewer RRT-free days with higher MAP target | −1.64 (−3.05 to −0.23) | P = 0.02 | |
| −4−202Difference (linear scale) |
Subgroups, incl. advanced age or chronic hypertension (subgroup)
- No benefit from higher targets for any patient group
Bayesian posterior probability of harm
- 28-day mortality
- 97.8%
- 90-day mortality
- 98.7%
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Arrhythmia | 1.32 (1.01–1.72) | P = 0.04 | |
| 0.512Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mortality effect of higher versus lower blood pressure targets in vasodilatory shock: an updated systematic review and meta-analysis. Crit Care. Published 23 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →