Hemodynamics, fluids & transfusion
Mean systemic filling pressure and venous return to assess the effects of passive leg raising and volume expansion in acute circulatory failure patients: a posthoc analysis of a multi-centre prospective study
Authors' conclusion
Venous return, derived from the mathematical model, increased in preload-dependent patients after VE and PLR because of the larger increases in Pmsf relative to CVP and the decreases in RVR. In preload-independent patients, VR did not change because of the larger rise in CVP compared to Pmsf after VE and PLR.
Study context
- Population
- Mechanically ventilated patients with acute circulatory failure
- Participants
- 202 participants
- Comparison
- Fluid responders vs non-responders after volume expansion (VE) and passive leg raising (PLR)
- Primary endpoint
- Behaviour of Pmsf (mathematical method) and derived venous return variables (dVR, RVR) after VE and PLR, by fluid and PLR responsiveness
Primary result
As reported in the abstract
Increase in dVR (Pmsf minus CVP) after VE
Fluid-responder
1.5
median · IQR 1.0–2.0 · mmHg
Non-responder
0.3
median · IQR −0.1–0.6 · mmHg
P < 0.001
Original publication
Mean systemic filling pressure and venous return to assess the effects of passive leg raising and volume expansion in acute circulatory failure patients: a posthoc analysis of a multi-centre prospective study. Anaesth Crit Care Pain Med. Published 7 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →