Hemodynamics, fluids & transfusion

Measurement error of pulse pressure variation

J Clin Monit ComputPublished Methodological study

Authors' conclusion

We showed that all methods that calculate PPV come with varying degrees of uncertainty.

Study context

Population
Patients undergoing liver transplantation, open-access VitalDatabase
Exposure
Three PPV calculation algorithms with different sampling period durations
Outcome
Measurement error (bias and precision) of PPV calculations
Methodological detailsretrospective analysis of open-access database, Bayesian model, Best Linear Unbiased Prediction reference, Hemodynamic data extracted from open-access VitalDatabase, 3 algorithms applied to calculate PPV on 1 min observation periods
  • Retrospective analysis of open-access database
  • Bayesian model
  • Best Linear Unbiased Prediction reference
  • Hemodynamic data extracted from open-access VitalDatabase
  • 3 algorithms applied to calculate PPV on 1 min observation periods

Main finding

As reported in the abstract

Measurement error of PPV methods

Range of differential bias

[- 0.04%, 1.64%]

Range of proportional bias

[0.92%, 1.17%]

Predicted range of reference PPV for measured PPV of 12%, two selected methods

[10.2%, 13.9%] and [10.3%, 15.1%]

Predicted range of reference PPV changes for measured absolute change of 1%, two selected methods

[- 1.3%, 3.3%] and [- 1.9%, 4%]

Observational data: associations, not effects.

Original publication

Measurement error of pulse pressure variation. J Clin Monit Comput. Published 8 December 2023. doi:10.1007/s10877-023-01099-x

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