Respiratory failure & ventilation
Mechanical power and 30-day mortality in mechanically ventilated, critically ill patients with and without Coronavirus Disease-2019: a hospital registry study
Main finding · 30-day mortality per 1-SD (7.1 J/min) increase in mechanical powerResult — go to the resultAdjusted odds ratio 1.26 95% CI 1.09–1.46Authors' conclusion
A higher mechanical power is associated with elevated 30-day mortality. While patients with COVID-19 received mechanical ventilation with higher mechanical power, this association was independent of a concomitant diagnosis of COVID-19.
Study context
- Population
- Critically ill adults mechanically ventilated for at least 24 h, March 2020–December 2021, tertiary healthcare facility in Boston, Massachusetts509 (29.3%) died within 30 days
- Participants
- 1,737 participants
- Exposure
- COVID-19 vs Without COVID-19
- COVID-19n = 411
- Outcome
- 30-day mortality (exposure: median mechanical power during first 24 h of ventilation; co-primary: effect modification by COVID-19)
- Follow-up
- 30 days
Methodological detailshospital registry, single tertiary centre, multivariable logistic regression
- Hospital registry
- Single tertiary centre
- Multivariable logistic regression
Main finding
As reported in the abstract
30-day mortality per 1-SD (7.1 J/min) increase in mechanical power
Adjusted odds ratio
1.26
95% CI 1.09–1.46
P = 0.002
Change by group
COVID-19
19.3
median · IQR 14.6–24.0 · J/min
Without COVID-19
13.2
median · IQR 10.2–18.0 · J/min
Higher mechanical power
aOR 1.26 (95% CI 1.09–1.46); P = 0.002
Per 1-SD, as printed
Observational data: associations, not effects.
Further findings
| Outcome | IRR (adjusted) (95% CI) | P value | |
|---|---|---|---|
| Days alive and ventilator free · day 28Higher mechanical power · per 7.1 J/min increase | 0.83 (0.75–0.91) | P < 0.001 | |
| 0.512Incidence rate ratio (adjusted) (log scale) |
| Outcome | Adjusted risk difference (days) (95% CI) |
|---|---|
| Days alive and ventilator free · day 28Higher mechanical power · per 7.1J/min increase | - 2.7 (- 4.1 to - 1.3) |
Original publication
Mechanical power and 30-day mortality in mechanically ventilated, critically ill patients with and without Coronavirus Disease-2019: a hospital registry study. J Intensive Care. Published 6 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →