Perioperative medicine & outcomes
Mechanical ventilation-induced neutrophil extracellular vesicles as mediators of postoperative pulmonary complications
Authors' conclusion
We identify a novel mechanistic pathway whereby mechanical ventilation induces NEV release, propagating alveolar inflammation via their biologically active cargo, which may be associated with PPCs.
Study context
- Population
- Patients undergoing esophagectomy requiring one- and two-lung ventilation
- Participants
- 42 patients
- Comparison
- OLV vs two-lung ventilation
- Outcome
- Neutrophil extracellular vesicles (EVs) (NEVs) in BAL
Methodological detailsserial bilateral bronchoalveolar lavage (BAL) sampling, in vitro alveolar stretch model
- Serial bilateral BAL sampling
- In vitro alveolar stretch model
Main finding
As reported in the abstract
OLV, but not two-lung ventilation, induced a marked increase in neutrophil-EVs (NEVs)
4.8-fold
Original publication
Mechanical ventilation-induced neutrophil extracellular vesicles as mediators of postoperative pulmonary complications. Am J Respir Crit Care Med. Published 15 September 2026. doi:10.
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