Perioperative medicine & outcomes
Mechanism-Based Modeling of Perioperative Variations in Hemoglobin Concentration in Patients Undergoing Laparoscopic Surgery
Authors' conclusion
Our model provides a mechanistic and quantitative understanding of the causes underlying the perioperative [Hb] variations.
Study context
- Population
- Patients undergoing laparoscopic surgery
- Participants
- 154 patients · 2 consecutive cohorts
- Comparison
- Development vs Validation
- Developmentn = 118
- Validationn = 36
- Outcome
- Perioperative variations in [Hb] and the variables and processes that govern them
- Follow-up
- Up to 96 hours postoperatively
Methodological detailsprospective, development and validation cohorts, nonlinear mixed-effects modelling, simulations
- Prospective
- Development and validation cohorts
- Nonlinear mixed-effects modelling
- Simulations
Main finding
As reported in the abstract
Urinary fluid elimination as share of total fluid elimination
24%
Simulated standard fluid therapy: hemodilution [Hb] decrease at end of surgery, responsible for lowest perioperative [Hb]
between 7 and 15 g/L
Original publication
Mechanism-Based Modeling of Perioperative Variations in Hemoglobin Concentration in Patients Undergoing Laparoscopic Surgery. Anesth Analg. Published 6 September 2023. doi:10.
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