Perioperative medicine & outcomes
Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis
Main findingResult — go to the resultOdds ratio 0.88 95% CI 0.73–1.05Authors' conclusion
Chronic metformin use was associated with slightly and nonsignificantly less delirium.
Study context
- Population
- Adults with type 2 diabetes having major noncardiac surgerycases = surgeries
- Exposure
- Chronic metformin use vs no metformin use
- Outcome
- Delirium
- Follow-up
- First 5 days after major noncardiac surgery
Methodological detailsinverse propensity score weighting, propensity score calibration
- Inverse propensity score weighting
- Propensity score calibration
Main finding
As reported in the abstract
Odds ratio
0.88
95% CI 0.73–1.05
P = 0.155
Events by group
Metformin users vs Nonmetformin users
OR 0.88 (95% CI 0.73–1.05); P = 0.155
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Metformin users | Nonmetformin users | Estimate | P value | |
|---|---|---|---|---|---|
| Composite of serious complications (MI, cardiac arrest, stage 2-3 AKI, mortality) | 3.3% | 11.7% | common-effect OR 0.67 (97.5% CI 0.39–1.17) | P = 0.106 | |
| Time to discharge alive | 3 (IQR 1–5) days | 3 (IQR 2–6) days | HR for early discharge 1.07 (CI 1.01–1.13) | ||
| 0.20.5125Ratio (log scale) |
Original publication
Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis. Anesth Analg. Published 20 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →