Hemodynamics, fluids & transfusion
Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials
Pooled result · MortalityResult — go to the resultRelative risk 0.60 95% CI 0.43–0.84Authors' conclusion
This meta-analysis showed that MB reverses vasodilation in critically ill and perioperative patients and might improve survival.
Study context
- Population
- Critically ill and perioperative patients
- Participants
- 556 participants · 11 RCTs
- Comparison
- Methylene blue vs control
- Outcome
- Mortality at the longest follow-up
- Follow-up
- Longest
Pooled result
Mortality
Relative risk
0.60
95% CI 0.43–0.84
P = 0.003
MB vs Control
RR 0.60 (95% CI 0.43–0.84); P = 0.003
As reported in the abstract
Further pooled results
| Outcome | MD (days) (95% CI) | P value | |
|---|---|---|---|
| ICU LOSMB vs Control | −0.9 (−1.06 to −0.77) | P < 0.001 | |
| Hospital LOSMB vs Control | −2.2 (−2.68 to −1.70) | P < 0.001 | |
| −4−202Difference, days (linear scale) |
| Outcome | MD (mmHg) (95% CI) | P value | |
|---|---|---|---|
| MAPMB vs Control | 8.4 (5.01–11.75) | P < 0.001 | |
| −5051015Difference, mmHg (linear scale) |
| Outcome | MD (dyn/s/cm5) (95% CI) | P value | |
|---|---|---|---|
| Systemic vascular resistanceMB vs Control | 94.5 (17.73–171.15) | P = 0.02 | |
| −1000100200Difference, dyn/s/cm5 (linear scale) |
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| COMB vs Control | 0.16 (−0.25 to 0.57) | P = 0.45 | |
| −0.500.51Difference (linear scale) |
Mortality, septic shock and cardiac surgery subgroups (subgroup)
- Lower mortality with methylene blue (MB) confirmed in septic shock and cardiac surgery subgroups
Original publication
Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials. J Cardiothorac Vasc Anesth. Published 1 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →