Hemodynamics, fluids & transfusion
Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue
An erratum to this article was published (J Cardiothorac Vasc Anesth, Apr 2026 ↗)
Pooled result · MAPResult — go to the resultMean difference 7.80 95% CI 2.63–12.98Authors' conclusion
Hydroxocobalamin appears to positively affect hemodynamics in shock, albeit similar to methylene blue.
Study context
- Population
- Adults receiving hydroxocobalamin for vasodilatory shock24 studies
- Comparison
- Hydroxocobalamin vs methylene blue
- Outcome
- Mean arterial pressure (MAP)
- Follow-up
- 1 hour
Methodological detailsrandom-effects models, Risk of Bias in Nonrandomized Studies of Interventions tool
- Random-effects models
- Risk of Bias in Nonrandomized Studies of Interventions tool
Pooled result
As reported in the abstract
Mean difference
7.80
95% CI 2.63–12.98
Hydroxocobalamin vs Methylene blue
mean difference 7.80 (95% CI 2.63–12.98)
Further pooled results
| Outcome | Mean difference (95% CI) | |
|---|---|---|
| Change in MAP from baseline · 1 hour | −4.57 (−16.05 to 6.91) | |
| Change in vasopressor dosage from baseline · 1 hour | −0.03 (−0.12 to 0.06) | |
| −20−10010Difference (linear scale) |
Mortality
- Mortality similar (OR)
- 0.92 (95% CI 0.42-2.03)
Original publication
Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue. J Cardiothorac Vasc Anesth. Published 7 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →