ICU sedation, delirium & recovery
Minimal Gain in Prognostic Certainty for Patients With Hematologic Malignancies Over 2 Weeks of Intensive Care: An Analysis to Inform Time-Limited Trials
Authors' conclusion
In patients with hematologic malignancies admitted to the ICU, prognostic certainty about long-term survival increased little during in the first 2 weeks of ICU admission, aside from increases in prognostic certainty due to early mortality.
Study context
- Population
- Patients with active hematologic malignancies admitted to the ICUICU admissions
- Participants
- 555 / 181 / 94
- Exposure
- Day 1 vs Day 7 vs Day 14
- Day 1n = 555
- Day 7n = 181
- Day 14n = 94
- Outcome
- Discrimination of prediction models for 1-year survival
Methodological detailstwo academic centres (The Netherlands), external validation (MIMIC-IV, US tertiary centre), prognostic model development
- Two academic centres (The Netherlands)
- External validation (MIMIC-IV, US tertiary centre)
- Prognostic model development
Main finding
As reported in the abstract
| Group | AUC |
|---|---|
| Day 1 | 0.71 |
| Day 7 | 0.67 |
| Day 14 | 0.66 |
AUC
Day 10.71
Day 70.67
Day 140.66
- Meaningful increase in prognostic certainty (entropy decrease > 0.25), day 1 to day 7
- 2%
- Additional certainty increase due to death, day 1 to day 7
- 12%
- Meaningful increase in prognostic certainty (entropy decrease > 0.25), day 7 to day 14
- 14%
- Additional certainty increase due to death, day 7 to day 14
- 18%
Observational data: associations, not effects.
Further findings
Shift to a more favorable prognostic category, day 1 to day 7 (alive on day 1)
- "Uncertain" initial prognosis
- 2%
- "Poor" initial prognosis
- 10%
Shift to a more favorable prognostic category, day 7 to day 14 (alive and in ICU on day 7)
- "Uncertain" prognosis
- 31%
- "Poor" prognosis
- 16%
External validation cohort
- Results comparable
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Minimal Gain in Prognostic Certainty for Patients With Hematologic Malignancies Over 2 Weeks of Intensive Care: An Analysis to Inform Time-Limited Trials. Crit Care Med. Published 7 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →