Minimum effective dose of carbetocin for preventing uterine atony during Cesarean delivery in patients with and without preeclampsia: a biased sequential allocation study
Authors' conclusion
The dose requirement of carbetocin to prevent intraoperative uterine atony in patients with preeclampsia is 1.5 times greater than in those without the disease.
Study context
- Population
- Nonlabouring parturients aged > 18 yr with singleton pregnancy for Cesarean delivery under spinal anesthesia, with and without preeclampsia
- Comparison
- Carbetocin ED90 in patients with vs without preeclampsia
- Outcome
- ED90 of carbetocin to prevent intraoperative uterine atony (success: satisfactory uterine tone at 2 min, no additional uterotonic)
Methodological detailsnonrandomized, triple-blinded, biased coin sequential allocation
- Nonrandomized
- Triple-blinded
- Biased coin sequential allocation
Main finding
As reported in the abstract
ED90 of carbetocin
Original publication
Minimum effective dose of carbetocin for preventing uterine atony during Cesarean delivery in patients with and without preeclampsia: a biased sequential allocation study. Can J Anaesth. Published 11 July 2025. doi:10.
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