The minimum effective dose (ED90) of prophylactic oxytocin infusion during cesarean delivery in patients with and without obesity: an up-down sequential allocation dose-response study
Main finding · ED90 of oxytocinResult — go to the resultRelative ratio 1.55 95% CI 1.09–2.01Authors' conclusion
Patients with obesity require a higher intra-operative oxytocin infusion dose rate to achieve a satisfactorily contracted uterus after fetal delivery when compared with patients without obesity.
Study context
- Population
- Patients undergoing cesarean delivery under subarachnoid block
- Participants
- 40 vs 40
- Exposure
- Oxytocin infusion ED90 in patients with vs without obesity
- Obesityn = 40
- Without obesityn = 40reference
- Outcome
- ED90 of oxytocin infusion for satisfactory uterine tone (graded by obstetrician 4 min after infusion start)
Methodological detailsprospective, dual-arm, 9:1 biased sequential allocation (up-down)
- Prospective
- Dual-arm
- 9:1 biased sequential allocation (up-down)
Main finding
ED90 of oxytocin
Relative ratio
1.55
95% CI 1.09–2.01
P = 0.019
By group
As reported in the abstract
Observational data: associations, not effects.
Original publication
The minimum effective dose (ED90) of prophylactic oxytocin infusion during cesarean delivery in patients with and without obesity: an up-down sequential allocation dose-response study. Int J Obstet Anesth. Published 1 December 2023. doi:10.
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