Minimum Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in Preterm and Term Pregnancy: A Sequential Allocation Dose Finding Study
Authors' conclusion
During cesarean delivery, oxytocin requirement is almost 1.5 times greater for preterm as compared to term pregnancy.
Study context
- Population
- Nonlaboring women >18 years posted for cesarean delivery under spinal block
- Participants
- 30 vs 30
- Comparison
- Oxytocin infusion ED90 in preterm vs term pregnancy
- Pretermn = 30
- Termn = 30reference
- Outcome
- ED90 of oxytocin infusion for satisfactory uterine tone (one-finger palpation by surgeon)
Methodological detailsbiased coin sequential allocation, triple blinding to dose allocation, Infusion started at 13 IU·h-1 in first patient of each group; dosing interval 2 IU·h-1
- Biased coin sequential allocation
- Triple blinding to dose allocation
- Infusion started at 13 IU·h-1 in first patient of each group; dosing interval 2 IU·h-1
Main finding
As reported in the abstract
ED90 of oxytocin infusion to prevent intraoperative uterine atony
Further findings
Intraoperative oxytocin amount · significantly greater in preterm
P = 0.048
Need of additional uterotonic
effect size 0.5 (0.1–2.5) · P = 0.448
| Outcome | P value |
|---|---|
| Myometrial oxytocin receptor expression (IHC)Increased expression for term vs preterm | P = 0.040 |
Safety
Oxytocin-associated hypotension
P = 0.002
Original publication
Minimum Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in Preterm and Term Pregnancy: A Sequential Allocation Dose Finding Study. Anesth Analg. Published 18 May 2026. doi:10.
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