Pediatric anesthesia & critical care
MiR-18a-5p serves as a risk factor in perioperative respiratory adverse events in children under general anesthesia
Authors' conclusion
The miR-18a-5p served as a predictive factor and held diagnostic significance for PRAEs following general anesthesia in children.
Study context
- Population
- Children undergoing GA
- Participants
- 174 children
- Comparison
- Perioperative respiratory adverse events (PRAEs) vs no PRAEs
- Outcome
- Serum miR-18a-5p expression and its diagnostic value for PRAEs (ROC curves)
Methodological detailsin vitro experiments
- In vitro experiments
Performance
As reported in the abstract
Serum miR-18a-5p
- Significantly elevated miR-18a-5p levels in PRAEs subjects, with diagnostic relevance
- Expression correlated positively with TNF-α/IL-6 concentrations and was associated with age, obesity, American Society of Anesthesiologists (ASA) grade and anaesthesia duration
- These parameters jointly constituted the PRAEs predictors
Further findings
In vitro AEC-II cells
- miR-18a-5p silencing enhanced viability, suppressed apoptosis and lipopolysaccharide (LPS)-triggered TNF-α and IL-6 release
Original publication
MiR-18a-5p serves as a risk factor in perioperative respiratory adverse events in children under general anesthesia. Perioper Med (Lond). Published 28 November 2025. doi:10.
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