Modelling the potential increase in eligible participants in clinical trials with inclusion of community intensive care unit patients in Alberta, Canada: a decision tree analysis
Authors' conclusion
Inclusion of community ICU patients in critical care research trials has the potential to substantially increase enrolment and decrease time to trial completion.
Study context
- Population
- All ICU patients in Alberta, Canada (2018 Alberta Health Services data), assessed against eligibility criteria of ten landmark randomised multicentre critical care trials10 trials modelled
- Comparison
- Academic plus community intensive care units (ICUs) vs academic ICUs only
- Outcome
- Number of additional eligible patients and change in time to study completion with inclusion of community ICUs
Methodological detailsmodelling study, population-level administrative data
- Modelling study
- Population-level administrative data
Main finding
As reported in the abstract
Potentially eligible patients for the ten trials, range
2,082 to 10,157
Share of potentially eligible participants from community ICUs
40.0%
Average increase in potential enrolment with community ICU patients
64.0%
Mean decrease in time to trial completion
14 months
43% reduction
Original publication
Modelling the potential increase in eligible participants in clinical trials with inclusion of community intensive care unit patients in Alberta, Canada: a decision tree analysis. Can J Anaesth. Published 21 December 2023. doi:10.
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