ICU sedation, delirium & recovery
Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study
Authors' conclusion
Modifications in ICU room design may influence the incidence and severity of delirium.
Study context
- Population
- Adult critically ill mechanically ventilated patients with expected ICU LOS ≥48 hours74 analysed
- Participants
- 74 participants
- Exposure
- Modified ICU room design vs standard rooms
- Outcome
- ICU delirium
Methodological detailsproof of concept, single university hospital, Sedation, delirium and pain assessed every 8 hours with validated scores; serum melatonin every 4 hours for up to three 24-hour periods
- Proof of concept
- Single university hospital
- Sedation, delirium and pain assessed every 8 hours with validated scores; serum melatonin every 4 hours for up to three 24-hour periods
Main finding
As reported in the abstract
Delirium incidence
P = 0.017
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Delirium severity2.3-fold higher | 2.292 (1.582–3.321) | P < 0.0001 | |
| 0.20.5125Odds ratio (log scale) |
Serum melatonin
- Light intensity (circadian effective irradiance) significantly influenced course of serum melatonin
- P < 0.0001
- Melatonin differences between standard and modified rooms varied over specific time periods (significant interactions)
- P < 0.001
Original publication
Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study. Crit Care Med. Published 19 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →