Neuroanesthesia & neurocritical care
Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study
Authors' conclusion
Our data suggest that TBI patients who developed VAP during ICU stay have different structures of BAL microbiota either at admission and at 7 days post-ICU admission, while no correlation has been observed between different enteral formulas and microbiota composition in terms of richness and evenness.
Study context
- Population
- Mechanically ventilated traumatic brain injury (TBI) patients in ICU
- Participants
- 31 participants
- Comparison
- Specialized vs standard enteral nutrition
- Specializedn = 16
- Standardn = 15reference
- Primary endpoint
- Lung microbiota (alpha and beta diversity of BAL samples)
- Follow-up
- Admission and 7 days post-ICU admission
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Lung microbiota beta diversity by nutrition
- Specialized nutrition influenced beta diversity, statistically significant only in Bray-Curtis distance
Further findings
Ventilator-associated pneumonia (VAP) incidence
- VAP in the first week
- 0
- Developed VAP thereafter
- 10/31
Bronco Alveolar Lavage (BAL) microbiota, VAP vs no VAP (retrospective grouping)
- Significant differences in beta diversity; Staphylococcus and Acinetobacter genera high in VAP
Original publication
Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study. Crit Care. Published 21 June 2023. doi:10.
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