Mortality trends for sepsis and septic shock among critically ill adults in Australia and New Zealand
Main finding · In-hospital mortality, 2023 vs 2000Result — go to the resultAdjusted odds ratio 0.48 95% CI 0.43–0.54Authors' conclusion
In-hospital mortality in adult ANZ ICU patients admitted with sepsis decreased significantly from 28% in 2000 to a nadir of 11% in 2020, independent of changes in case-mix.
Study context
- Population
- Adult intensive care unit (ICU) patients admitted with sepsis (Sepsis-3 definition), 219 ICUs in Australia and New Zealand, January 2000 to June 2023
- Participants
- 303,389 patients · 2,975,149 ICU admissions
- Exposure
- In-hospital mortality over time, 2000–2023
- Outcome
- In-hospital mortality over time
Methodological detailsmulticentre registry, logistic regression
- Multicentre registry
- Logistic regression
Main finding
In-hospital mortality, 2023 vs 2000
Adjusted odds ratio
0.48
95% CI 0.43–0.54
2023 vs 2000
aOR 0.48 (95% CI 0.43–0.54)
As reported in the abstract
- In-hospital mortality in 2000
- 28%
- In-hospital mortality in 2023
- 13%
Observational data: associations, not effects.
Further findings
Trend in in-hospital mortality by period
- Decrease per year, 2000-2013
- 1.1%
- Decrease per year, 2013-2020 (p < 0.001 for change in slope)
- 0.3%
- Increase per year, 2020-2023 (p < 0.001)
- 0.9%
- Nadir in 2020
- 11%
- Linear decrease per year 2000 to 2020, independent of measurable confounding
- 4%
Contemporary in-hospital mortality by subgroup
- Septic shock
- 25%
- Invasive mechanical ventilation
- 20%
Original publication
Mortality trends for sepsis and septic shock among critically ill adults in Australia and New Zealand. Intensive Care Med. Published 3 November 2025. doi:10.
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