Moving toward a contemporary classification of drug-induced kidney disease
Authors' conclusion
This new classification system allows congruencies for DIKD with the proposed categorization of AKI, offering clarity as well as consistency for clinicians and researchers.
Study context
- Population
- Drug-induced kidney disease (DIKD), incl. Acute kidney injury (AKI) in hospitalized and critically ill patients
- Outcome
- Proposed DIKD classification framework (functional change and tissue damage biomarkers)
Main finding
As reported in the abstract
- Medications stratified into 4 categories: "dysfunction without damage", "damage without dysfunction", "both dysfunction and damage", "neither dysfunction nor damage", with predominant mechanism(s) of nephrotoxicity
- Possible movement of a patient's kidney disease between certain categories in specific conditions
- Opportunities and barriers to adoption in clinical practice discussed
Further findings
Burden of DIKD
- DIKD accounts for about one-fourth of all AKI cases in hospitalized patients, especially critically ill
Original publication
Moving toward a contemporary classification of drug-induced kidney disease. Crit Care. Published 9 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →