Pediatric anesthesia & critical care
Multicentre analysis of severe perioperative adverse events in children undergoing surgery who were infected with SARS-CoV-2: a propensity score-adjusted analysis
Main finding · At least one severe adverse eventResult — go to the resultAdjusted odds ratio 2.34 95% CI 1.25–4.39Authors' conclusion
In the largest cohort to date of paediatric patients undergoing general anaesthesia, SARS-CoV-2 infection was associated with severe perioperative adverse events, but no children in the infected cohort died.
Study context
- Population
- Children <18 years, ASA PS 1–4, non-severe SARS-CoV-2, undergoing GA at 21 North American institutions, April 1, 2020 to March 31, 2021
- Participants
- 4,534 children · 21 institutions
- Exposure
- SARS-CoV-2 positive vs non-infected children undergoing GA
- SARS-CoV-2n = 1,138
- Non-infectedn = 3,396reference
- Outcome
- Severe perioperative adverse events:
- ICU admission for escalation of respiratory support
- ARDS
- Postoperative pneumonia
- Cardiovascular arrest
- Extracorporeal life support
- Death
- Follow-up
- Within 7 days of the anaesthetic
Methodological detailsmulticentre, propensity score-adjusted, inverse probability of treatment weighting
- Multicentre
- Propensity score-adjusted
- Inverse probability of treatment weighting
Main finding
At least one severe adverse event
Adjusted odds ratio
2.34
95% CI 1.25–4.39
Events by group
SARS-CoV-2 vs Non-infected
aOR 2.34 (95% CI 1.25–4.39)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Severe adverse events, overall sample
- 52 of 4534 had a severe adverse event
Safety
- Cardiac arrest, extracorporeal life support or death in SARS-CoV-2 children
- 0 · events
Original publication
Multicentre analysis of severe perioperative adverse events in children undergoing surgery who were infected with SARS-CoV-2: a propensity score-adjusted analysis. Br J Anaesth. Published 16 November 2024. doi:10.
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