Pediatric anesthesia & critical care
Association between preoperative respiratory symptoms and perioperative respiratory adverse events in pediatric patients with positive viral testing
Authors' conclusion
There was no significant difference in the incidence of PRAE between symptomatic and asymptomatic children with laboratory confirmed viral respiratory infection, and between children with the Omicron variant of SARS-CoV-2 compared to non-SARS-CoV-2 respiratory viruses. However, the risk was increased in children with recent fever.
Study context
- Population
- Children <18 years with positive respiratory viral testing undergoing GA, tertiary pediatric hospital, Dallas, Texasconvenience sample
- Participants
- 196 children
- Exposure
- Symptomatic vs asymptomatic children with positive viral testing; SARS-CoV-2 vs non-SARS-CoV-2 infection
- Symptomaticn = 83
- Asymptomaticn = 113reference
- Outcome
- Composite PRAE:
- SpO2 < 90% for >5 min
- Supplemental oxygen >2 h after anesthesia
- Laryngospasm
- Bronchospasm
Methodological detailssingle-centre, convenience sample
- Single-centre
- Convenience sample
Main finding
As reported in the abstract
Each group vs asymptomaticRisk difference, % (95% CI)
Symptomatic
−1.9(−10.9 to 7.9)
Each group vs asymptomaticMultivariable adjusted odds ratio (95% CI)
Symptomatic
0.68(0.25–1.85)
Observational data: associations, not effects.
Secondary outcomes
Perioperative respiratory adverse events (PRAE), documented fever within 48 h of anesthetic (subgroup)
| Risk difference (%) (95% CI) | ||
|---|---|---|
| Fever within 48 h | 20.8 (5.3–39.7) | |
| −2002040Difference, % (linear scale) |
| Outcome | Multivariable adjusted OR (95% CI) | |
|---|---|---|
| PRAE, SARS-CoV-2 vs non-SARS-CoV-2 infection | 0.46 (0.14–1.44) | |
| 0.10.31310Multivariable adjusted odds ratio (log scale) |
Original publication
Association between preoperative respiratory symptoms and perioperative respiratory adverse events in pediatric patients with positive viral testing. J Clin Anesth. Published 31 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →