Multimodal Analgesia Bundle and Postoperative Opioid Use Among Patients Undergoing Colorectal Surgery
An erratum to this article was published (JAMA Netw Open, 2 Feb 2026 ↗)
Authors' conclusion
In this cohort study of 842 patients undergoing colorectal surgery, a care bundle consisting of an individualized opioid regimen, regular gabapentin, and clonidine as a rescue analgesic was found to be associated with a significant decrease in opioids consumed postoperatively.
Study context
- Population
- Patients undergoing major colorectal surgery at Ersta Hospital, Stockholm, Sweden, 2016–2019
- Participants
- 842 patients
- Exposure
- 2019 vs 2016
- Outcome
- In-hospital administered IV and oral opioids (MME)
- Follow-up
- Day of surgery and first 5 postoperative days
Methodological detailssingle-centre, multivariable linear regression, Data analysis February 1, 2020, to May 30, 2022
- Single-centre
- Multivariable linear regression
- Data analysis February 1, 2020, to May 30, 2022
Main finding
As reported in the abstract
Opioid usage (MME)
P < 0.001
Observational data: associations, not effects.
Further findings
Proportion receiving ≤45 MME
P < 0.001
Association of bundle components and age with opioid consumption (multivariable analysis)
- Individualized opioid strategy: β (SE 3.8; P = .003)
- −11.6
- Gabapentin: β (SE 4.5; P < .001)
- −39.1
- Increasing age: β (SE 0.11; P < .001)
- −1.0
- Clonidine (more opioid intake): β (SE 3.6; P = .001)
- 11.6
- F5, 836 = 57.5; P < .001
Original publication
Multimodal Analgesia Bundle and Postoperative Opioid Use Among Patients Undergoing Colorectal Surgery. JAMA Netw Open. Published 5 September 2023. doi:10.
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