Multimorbidity and analgesic-related harms: a systematic review
Authors' conclusion
There is evidence of harms associated with opioids in adults with multimorbidity, including overdose and increased mortality. There is a lack of evidence on gabapentinoids.
Study context
- Population
- Adults with multimorbidity (two or more long-term medical conditions) exposed to analgesics
- Participants
- 2,671,958 adults · 27 studies
- Comparison
- Opioids, nonsteroidal anti-inflammatory drugs (NSAIDs) and gabapentinoids: analgesic-related harms in adults with multimorbidity
- Outcome
- Risk of adverse outcomes from opioids, NSAIDs and gabapentinoids
Methodological detailsnarrative synthesis, Newcastle-Ottawa risk of bias assessment
- Narrative synthesis
- Newcastle-Ottawa risk of bias assessment
Pooled result
As reported in the abstract
Analgesic-related adverse outcomes
| Group | Value | Studies reporting adverse outcomes |
|---|---|---|
| Opioids | 12/16 events | 12/16 |
| NSAIDs | 6/11 events | 6/11 |
Value
Opioids12/16 events
NSAIDs6/11 events
Studies reporting adverse outcomes
Opioids12/16
NSAIDs6/11
Original publication
Multimorbidity and analgesic-related harms: a systematic review. Br J Anaesth. Published 20 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →