Hemodynamics, fluids & transfusion
Multisystem hemodynamic effects of terlipressin in cirrhosis: A scoping review
Authors' conclusion
Terlipressin exerts a variety of hemodynamic effects across organ systems and vascular beds.
Study context
- Population
- Adults with cirrhosis receiving terlipressin with hemodynamic parameters recorded56 studies
- Outcome
- Hemodynamic effects of terlipressin
Methodological details2022 studies retrieved, 56 met inclusion criteria, Searches up to December 2024: MEDLINE, Embase, Cochrane Library, Scopus, Web of Science, CINAHL
- 2022 studies retrieved, 56 met inclusion criteria
- Searches up to December 2024: MEDLINE, Embase, Cochrane Library, Scopus, Web of Science, CINAHL
Main finding
As reported in the abstract
- Decreased heart rate
- Increased MAP
- Decreased cardiac output/index
- Increased systemic vascular resistance
- Other hemodynamic outcomes more varied across studies
Further findings
Parameters reported
- Heart rate, MAP and CO most reported; pulmonary arterial and wedge pressure next; systemic vascular resistance, hepatic and renal measures fewer studies
Original publication
Multisystem hemodynamic effects of terlipressin in cirrhosis: A scoping review. J Crit Care. Published 16 February 2025. doi:10.
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