Respiratory failure & ventilation
A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score)
Authors' conclusion
The IPA-GRRR-OH is a clinical score, easily available at ICU admission, which reliably predicts IPA in immunocompromised patients with acute respiratory failure.
Study context
- Population
- Immunocompromised patients with acute respiratory failure admitted to 12 intensive care units (ICUs)12 ICUs
- Participants
- 3,262 vs 776
- Comparison
- Derivation vs validation cohort
- Derivationn = 3,262
- Validationn = 776
- Outcome
- Diagnosis of probable or proven IPA (risk prediction model)
Methodological detailsderivation and prospective validation cohorts, multicentre
- Derivation and prospective validation cohorts
- Multicentre
Performance
As reported in the abstract
Discrimination of the IPA-GRRR-OH score for IPA diagnosis
| Test or model | AUC |
|---|---|
| Derivation | 0.72 [0.68-0.76] |
| Validation | 0.85 [0.76-0.93] |
AUC
Derivation0.72 [0.68-0.76]
Validation0.85 [0.76-0.93]
Further findings
IPA prevalence
Median
| Outcome | Derivation | Validation |
|---|---|---|
| IPA-GRRR-OH score | 2 (IQR 1–3) | 1 (IQR 0–3) |
Original publication
A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score). Intensive Care Med. Published 24 January 2025. doi:10.
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