Respiratory failure & ventilation
Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients
Authors' conclusion
In orally intubated patients, NHF was associated with lower dyspnea and lower respiratory drive without affecting the inspiratory work.
Study context
- Population
- Orally intubated patients on pressure support ventilation with dyspnea-NRS score >3crossover
- Participants
- 20 participants
- Comparison
- Nasal high flow at 30, 50 and 60 L/min vs 0 L/min during pressure support ventilation; 50 vs 0 L/min during spontaneous breathing trial (SBT)
Methodological detailsrandomized order of nasal high flow (NHF) flow rates
- Randomized order of NHF flow rates
Primary result
As reported in the abstract
Dyspnea-NRS score during pressure support ventilation
NHF 0 L/min
5
range 4–6
NHF 30 L/min
3
range 2–6
NHF 50 L/min
3
range 2–5
P < 0.05
Further findings
| Outcome | P value |
|---|---|
| Dyspnea-NRS score and P0.1 during SBTNHF 50 L/min vs NHF 0 L/min | P < 0.01 |
| Dyspnea-NRS score and P0.1 during SBTNHF 50 L/min vs NHF 0 L/min | P = 0.04 |
Dyspnea-NRS score and P0.1 during SBT
- MV-RDOS score, esophageal pressure and respiratory muscle EMG did not change
Original publication
Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients. Am J Respir Crit Care Med. Published 1 April 2025. doi:10.
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