Neuraxial Use Among Total Knee and Hip Arthroplasty Patients With Multiple Sclerosis or Myasthenia Gravis
Authors' conclusion
Neuraxial anesthesia use was lower in surgical patients with multiple sclerosis compared to the general population but no different in those with myasthenia gravis. Neuraxial use was associated with lower odds of prolonged length of stay.
Study context
- Population
- TKA/THA recipients, Premier Health Database, 2006–2019TKA/THAs
- Participants
- 2,184,193 recipients
- Exposure
- Multiple sclerosis or myasthenia gravis vs general population
- Multiple sclerosisn = 7,559
- Myasthenia gravisn = 3,176
- Outcome
- Neuraxial anesthesia use
Methodological detailsPremier Health Database
- Premier Health Database
Main finding
As reported in the abstract
Each group vs general populationOdds ratio (CI)P value
Multiple sclerosis
0.61(0.57–0.65)
P < 0.0001Myasthenia gravis
1.05(0.96–1.14)
P = 0.304Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Prolonged LOS, multiple sclerosis subgroup (neuraxial vs no neuraxial)Mirroring benefits seen in the general population | 0.63 (0.53–0.76) | P < 0.0001 | |
| 0.512Odds ratio (log scale) |
Original publication
Neuraxial Use Among Total Knee and Hip Arthroplasty Patients With Multiple Sclerosis or Myasthenia Gravis. Anesth Analg. Published 20 March 2023. doi:10.
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