Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study
Main finding · Major neurologic complicationsResult — go to the resultOdds ratio 1.53 95% CI 1.02–2.31Authors' conclusion
In this analysis of the PELS Study, Subclavian/Axillary cannulation was associated with higher rates of major neurologic complications and seizures. In-hospital mortality was higher after Aortic cannulation, despite no significant differences in incidence of neurological cause of death in these patients.
Study context
- Population
- Adults requiring post-cardiotomy extracorporeal life support (ECLS), PELS Study database, January 2000–December 2020
- Participants
- 1,897 adults · 34 centres
- Exposure
- Aortic vs Subclavian/Axillary vs Femoral
- Aorticn = 503
- Subclavian/Axillaryn = 397
- Femoraln = 997
- Outcome
- Composite major neurologic complications:
- Ischemic stroke
- Cerebral hemorrhage
- Brain edema
Methodological detailsmulticentre (34 centres), observational, mixed-effects model adjustment, Neuro-monitoring used infrequently in all groups
- Multicentre (34 centres)
- Observational
- Mixed-effects model adjustment
- Neuro-monitoring used infrequently in all groups
Main finding
Major neurologic complications
Odds ratio
1.53
95% CI 1.02–2.31
P = 0.041
Events by group
Subclavian/Axillary
OR 1.53 (95% CI 1.02–2.31); P = 0.041
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Seizures (minor neurologic complications)
P = 0.036
In-hospital mortality · Kaplan-Meier curves
P < 0.001
Neurologic cause of death
P = 0.433
Original publication
Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study. Crit Care. Published 7 August 2024. doi:10.
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