Perioperative medicine & outcomes
New onset postoperative depression after major surgery: an analysis from a national claims database
Authors' conclusion
The risk of postoperative depression differs by surgical type after controlling for preoperative characteristics.
Study context
- Population
- Patients undergoing major surgery, Optum Clinformatics Datamart, January 2004 to June 2021
- Participants
- 132,390 / 12,538 / 32,630 / 96,750 / 157,484 / 347,878
- Exposure
- Surgical types vs laparoscopic cholecystectomy
- Cardiac surgeryn = 132,390
- Thoracotomyn = 12,538
- Video-assisted thoracoscopic surgery (VATS)n = 32,630
- Hip fracture surgeryn = 96,750
- Hip replacementn = 157,484
- Laparoscopic cholecystectomyn = 347,878reference
- Outcome
- New onset postoperative depression (new diagnosis of depression or new antidepressant prescription; International Classification of Diseases (ICD) 9/10 codes and drug names)
- Follow-up
- 1 year after surgery
Methodological detailsnational claims database, multivariable Cox regression, propensity score matching
- National claims database
- Multivariable Cox regression
- Propensity score matching
Main finding
As reported in the abstract
Each group vs laparoscopic cholecystectomyHazard ratio (95% CI)
Hip fracture surgery
1.56(1.45–1.68)
Thoracotomy
1.12(1.03–1.22)
Cardiac surgery
1.09(1.04–1.12)
VATS
0.95(0.90–1.00)
Hip replacement
0.55(0.52–0.57)
Observational data: associations, not effects.
Further findings
Propensity score matched and sensitivity analyses (new diagnosis and new antidepressant, or either separately)
- Results similar
Original publication
New onset postoperative depression after major surgery: an analysis from a national claims database. BJA Open. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →