Non-inferiority randomized controlled trial comparing CricOid pressure and para-laryngeal pressure in parturients undergoing cesarean delivery: NiCOP trial
Primary resultResult — go to the resultMean difference −0.11 cm 95% CI −0.17 to −0.1Authors' conclusion
Para-laryngeal pressure was non-inferior to CP in occluding the esophagus in parturients undergoing cesarean delivery under general anesthesia and furthermore, no significant deterioration in intubation parameters was seen.
Study context
- Population
- Parturients scheduled for elective cesarean delivery under GA
- Participants
- 40 participants
- Comparison
- Para-laryngeal pressure vs cricoid pressure during RSI
- CPn = 20reference
- Para-laryngeal (PL)n = 20
- Primary endpoint
- Change in antero-posterior diameter of the esophagus, measured by sonography
Methodological detailsprospective, non-inferiority
- Prospective
- Non-inferiority
Primary result
As reported in the abstract
Mean difference
−0.11 cm
95% CI −0.17 to −0.1
P < 0.001
By group
CP vs PL
mean difference −0.11 cm (95% CI −0.17 to −0.1); P < 0.001
Secondary outcomes
- No significant difference in percentage of glottic opening (POGO) score
- P = 0.818
- No significant difference in time to intubation
- P = 0.55
- No significant difference in intubation attempts
- P = 0.99
Original publication
Non-inferiority randomized controlled trial comparing CricOid pressure and para-laryngeal pressure in parturients undergoing cesarean delivery: NiCOP trial. Int J Obstet Anesth. Published 17 April 2024. doi:10.
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