Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis
Authors' conclusion
Lidocaine (most effective), ketamine, and gabapentinoids could be effective in reducing chronic postsurgical pain ≤6 months although confidence is low.
Study context
- Population
- Surgical patients receiving non-opioid analgesics for prevention of chronic postsurgical pain
- Participants
- 23,902 patients · 132 RCTs
- Comparison
- Non-opioid analgesics for prevention of chronic postsurgical pain
- Outcome
- Incidence of chronic postsurgical pain
- Follow-up
- ≤6 months
Methodological detailsPRISMA-NMA-compliant
- PRISMA-NMA-compliant
Pooled result
As reported in the abstract
Odds ratio (95% CrI)
i.v. lidocaineCrI
0.32(0.17–0.58)
KetamineCrI
0.64(0.44–0.92)
GabapentinoidsCrI
0.67(0.47–0.92)
DexmedetomidineCrI; possibly reduced
0.36(0.12–1.00)
Further pooled results
CPSP >6 months, combination agents, chronic opioid use
- Little available evidence
Safety
Serious adverse events
- Little available evidence
Original publication
Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis. Br J Anaesth. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →