Non-pulmonary complications of intrathecal morphine administration: a systematic review and meta-analysis with meta-regression
Authors' conclusion
Intrathecal morphine significantly increased postoperative nausea and vomiting, pruritus, and urinary retention after surgery or labour in a dose-independent manner.
Study context
- Population
- Patients undergoing any type of surgery under general or spinal anaesthesia, or women in labour
- Participants
- 9,917 patients · 168 trials
- Comparison
- Intrathecal morphine vs control
- Outcome
- Rates of PONV, pruritus, and urinary retention
- Follow-up
- First 24 postoperative hours
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
PONV, pruritus, urinary retention
Intrathecal morphine vs ControlOdds ratio (95% CI)P value
PONV
1.52(1.29–1.79)
P < 0.0001Pruritus
6.11(5.25–7.10)
P < 0.0001Urinary retention
1.73(1.17–2.56)
P = 0.005Further pooled results
Dose–complication association (meta-regression)
- No association between dose and rates of non-pulmonary complications established
Subgroups by type of surgery (subgroup)
- No subgroup difference according to surgery for any outcome
Original publication
Non-pulmonary complications of intrathecal morphine administration: a systematic review and meta-analysis with meta-regression. Br J Anaesth. Published 3 August 2024. doi:10.
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