Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial
Primary result · Change in BIS after tracheal intubationResult — go to the resultMean difference −1.13 95% CI −4.87 to 2.62Authors' conclusion
Dexmedetomidine demonstrated an anaesthetic-sparing effect at induction of anaesthesia but did not prevent EEG arousal after tracheal intubation, as defined by an increase in the BIS value.
Study context
- Population
- Patients aged 18–40 yr undergoing intubation for GAincluded in primary analysis
- Participants
- 51 patients
- Comparison
- Dexmedetomidine vs placebo
- Primary endpoint
- Change in BIS from pre- to postintubation
Methodological detailsplacebo-controlled, single-site, sex-based stratification
- Placebo-controlled
- Single-site
- Sex-based stratification
Primary result
Change in BIS after tracheal intubation
Mean difference
−1.13
95% CI −4.87 to 2.62
P = 0.556
Dexmedetomidine vs Placebo
mean difference −1.13 (95% CI −4.87 to 2.62); P = 0.556
As reported in the abstract
Further findings
| Outcome | Difference (μg ml-1) (95% CI) | P value | |
|---|---|---|---|
| Estimated plasma propofol concentration at loss of responsiveness | −1.06 (−1.66 to −0.46) | P < 0.001 | |
| Estimated plasma propofol concentration before intubation | −1.84 (−2.79 to −0.90) | P < 0.001 | |
| −4−202Difference, μg ml-1 (linear scale) |
| Outcome | Placebo |
|---|---|
| Positive isolated forearm test before and after tracheal intubation | 1 events |
Original publication
Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial. BJA Open. Published 16 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →