Obesity Paradox and Functional Outcomes in Sepsis: A Multicenter Prospective Study
Authors' conclusion
Obesity is associated with higher hospital survival and functional outcomes at discharge in Asian patients with sepsis.
Study context
- Population
- Adults with sepsis at 19 tertiary referral or university-affiliated hospitals in South Korea, September 2019 to December 2020
- Participants
- 6,424 adults
- Exposure
- Obese vs nonobese patients with sepsis
- Obesen = 1,335
- Nonobesen = 5,089reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, propensity-score matched (1:1)
- Multicentre
- Propensity-score matched (1:1)
Main finding
As reported in the abstract
Hospital mortality
P < 0.001
Observational data: associations, not effects.
Further findings
Home discharge rate · after propensity score matching
P < 0.001
Frail patients (CFS ≥ 5) · at discharge · significantly higher in nonobese · after propensity score matching
P = 0.011
Median
| Outcome | Obese | Nonobese | aOR | P value |
|---|---|---|---|---|
| Clinical Frailty Scale (CFS) · at dischargeAfter propensity score matching | 4 | 5 | P = 0.007 | |
| Hospital mortality by WHO BMI class (vs normal BMI)Underweight vs Normal BMI | 1.25 | P = 0.004 | ||
| Hospital mortality by WHO BMI class (vs normal BMI)Overweight vs Normal BMI | 0.58 | P < 0.001 | ||
| Hospital mortality by WHO BMI class (vs normal BMI)Obese vs Normal BMI | 0.70 | P = 0.047 | ||
| Frailty at discharge by WHO BMI class (vs normal BMI)Underweight vs Normal BMI | 1.53 | P < 0.001 | ||
| Frailty at discharge by WHO BMI class (vs normal BMI)Overweight vs Normal BMI | 0.80 | P = 0.095 | ||
| Frailty at discharge by WHO BMI class (vs normal BMI)Obese vs Normal BMI | 0.60 | P = 0.022 |
Original publication
Obesity Paradox and Functional Outcomes in Sepsis: A Multicenter Prospective Study. Crit Care Med. Published 9 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →