The impact of coagulopathy on prognosis in critically ill patients with sepsis: A nationwide cohort study
Authors' conclusion
In this nationwide cohort, sepsis-induced coagulopathy was associated with higher 28-day mortality but not with a significantly increased risk of major bleeding.
Study context
- Population
- Sepsis patients from 15 hospitals in South Korea, September 2019–December 2022from cohort of 13,827
- Participants
- 3,217 patients
- Exposure
- Sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC) vs SIC
- SIC (-)n = 1,696reference
- SIC (+)n = 932
- DIC (+)n = 589
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsnationwide, multicentre
- Nationwide
- Multicentre
Main finding
As reported in the abstract
Each group vs SIC (-)Adjusted hazard ratio (95% CI)P value
SIC (+)
1.35(1.16–1.58)
P < 0.001DIC (+)
1.59(1.33–1.90)
P < 0.001Observational data: associations, not effects.
Safety
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Major bleeding eventsDIC (+) vs SIC (-) · secondary outcome | 2.02 (1.03–3.88) | P = 0.036 | |
| Major bleeding eventsSIC (+) vs SIC (-) · secondary outcome | 1.20 (0.60–2.33) | P = 0.600 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Major bleeding events
- Infrequent across all groups
Original publication
The impact of coagulopathy on prognosis in critically ill patients with sepsis: A nationwide cohort study. J Crit Care. Published 22 January 2026. doi:10.
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