Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
Authors' conclusion
CPI can predict the 28-day survival of septic patients with DIC who have undergone antithrombin treatment.
Study context
- Population
- Septic disseminated intravascular coagulation (DIC) patients treated with antithrombin concentrate
- Comparison
- Derivation vs Validation
- Derivationn = 1,492
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsderivation cohort from post-marketing surveys, validation cohort from nationwide sepsis registry
- Derivation cohort from post-marketing surveys
- Validation cohort from nationwide sepsis registry
Performance
As reported in the abstract
Prediction of 28-day survival by composite prognostic index (CPI)
| Test or model | AUROC |
|---|---|
| Derivation | 0.76 |
| Validation | 0.71 |
AUROC
Derivation0.76
Validation0.71
Further findings
Independent predictors of death (multivariable analysis)
| HR (95% CI) | P value | ||
|---|---|---|---|
| DIC resolution | 0.31 (0.22–0.45) | P < 0.0001 | |
| Rate of SOFA score change | 0.42 (0.36–0.50) | P < 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
- 28-day mortality, derivation cohort · 28 days
- 16.9% · 252 of 1492
Original publication
Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation. J Intensive Care. Published 24 June 2024. doi:10.
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