Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study
Authors' conclusion
The combined use of the DIC score and PT-INR helps in selecting the optimal patient population for anticoagulant therapy in sepsis-induced DIC.
Study context
- Population
- Adults with severe sepsis from 59 ICUs in Japan, January 2016 to March 20171,013 analysed
- Participants
- 1,178 adults
- Comparison
- Anticoagulant therapy vs none, by DIC score and prothrombin time-international normalized ratio (PT-INR)
Methodological detailsretrospective sub-analysis, multivariable regression with interaction terms, three-way interaction analysis
- Retrospective sub-analysis
- Multivariable regression with interaction terms
- Three-way interaction analysis
Primary result
As reported in the abstract
Organ dysfunction, in-hospital mortality and anticoagulant therapy benefit by DIC score and PT-INR
- Organ dysfunction and in-hospital mortality worsened with higher PT-INR (range < 1.5), more pronounced with higher DIC scores
- Anticoagulant therapy associated with better survival in patients with high DIC score and high PT-INR
- Clinical threshold for optimal anticoagulant therapy targets: DIC score ≥ 5 and PT-INR ≥ 1.5
- Three-way interaction analysis
Original publication
Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study. J Intensive Care. Published 5 March 2023. doi:10.
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