Perioperative medicine & outcomes
Objective Activity Parameters Track Patient-specific Physical Recovery Trajectories After Surgery and Link With Individual Preoperative Immune States
Authors' conclusion
Accelerometry-based recovery trajectories are scalable and objective outcomes to study patient-specific factors that drive physical recovery.
Study context
- Population
- Patients undergoing major joint replacement surgery
- Outcome
- Whether accelerometry-derived objective physical parameters accurately track patient-specific physical recovery profiles, vs benchmark metrics incl. step count, and link with preoperative immune state
Methodological detailsaccelerometry, deep immune profiling, cross-validated canonical-correlation analysis
- Accelerometry
- Deep immune profiling
- Cross-validated canonical-correlation analysis
Main finding
As reported in the abstract
- Patient-specific temporal patterns of physical function derived with precision superior to benchmark metrics
- 6 distinct domains of physical function and sleep identified: activity capacity and moderate and overall activity declined immediately after surgery; sleep disruption and sedentary activity increased after surgery; overall sleep, sleep onset and light activity showed no clear changes
- Patterns linked to individual preoperative immune state (cross-validated canonical-correlation analysis)
- pSTAT3 signal activity in monocytic myeloid-derived suppressor cells predicted slower recovery
Observational data: associations, not effects.
Original publication
Objective Activity Parameters Track Patient-specific Physical Recovery Trajectories After Surgery and Link With Individual Preoperative Immune States. Ann Surg. Published 8 October 2021. doi:10.
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