Perioperative medicine & outcomes
Odor Enrichment Attenuates the Anesthesia/Surgery-induced Cognitive Impairment
Authors' conclusion
The anesthesia/surgery-induced olfactory impairment may contribute to dNCR in patients and postoperative cognitive impairment in mice.
Study context
- Population
- Patients undergoing anesthesia/surgery; mice
- Exposure
- Delayed neurocognitive recovery (dNCR) vs No dNCR
- Outcome
- Association between olfactory impairment (odor identification) and dNCR
Main finding
As reported in the abstract
Odor identification score, preoperative · preoperative
dNCR
7
median · IQR 1.25–9
No dNCR
10
median · IQR 8–11
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | dNCR | P value |
|---|---|---|
| Odor identification score, postoperative | median 8 (IQR 2.25–10) | P < 0.001 |
Mice: effects of anesthesia/surgery and their attenuation
- Anesthesia/surgery induced olfactory and cognitive impairment, increased IL-6 in blood and nasal epithelium, decreased olfactory receptor neurons and their markers in nasal epithelium, and reduced hippocampal synapse markers
- These changes attenuated by odor enrichment and IL-6 antibody
Original publication
Odor Enrichment Attenuates the Anesthesia/Surgery-induced Cognitive Impairment. Ann Surg. Published 18 July 2022. doi:10.
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